The One Sai Gon is on Đặng Thị Nhu street in District 1, the commercial and historic centre of Ho Chi Minh City, home to the Opera House, the Central Post Office and Independence Palace. Several cafés and restaurants are within 50 m, including Vitis Restaurant, Royal Sài Gòn and Air Saigon, and the Chùa Trường Thạnh pagoda is also 50 m away. Guests find the setting central but quiet, and the rooftop pool is a calm place to sit above the city. The Nguyen Hue walking street and Dong Khoi are also in District 1.
Ben Thanh Station, a metro station, is 250 m away, and the Saigon Railway Station is 2.6 km away. Long-distance trains from across the country arrive at the Saigon Railway Station. Tan Son Nhat International Airport lies 5.7 km from the property, a trip usually made by taxi or ride-hailing, and the Sài Gòn bus station, Bến xe buýt Sài Gòn, is 850 m away.
Ben Thanh Market, a covered market for food, clothes and souvenirs, is 400 m away on foot, and Chợ Dân Sinh, a traditional market for fresh produce, is 300 m away. September 23 Park, 350 m away, is a green space good for a morning walk, and the Ho Chi Minh City Fine Arts Museum, 250 m away, shows a collection of Vietnamese painting and sculpture.